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Original laboratory certificate
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5-Amino-1MQ is a small-molecule methylquinolinium compound studied as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT catalyzes the methylation of nicotinamide using S-adenosylmethionine as a methyl donor, a reaction that sits at the intersection of NAD⁺ salvage and cellular methylation balance. In published research, inhibition of NNMT is associated with elevated intracellular NAD⁺ levels and altered adipocyte metabolic activity in cell-culture and model systems, which is why 5-Amino-1MQ is widely used as a reference tool compound for investigating NNMT activity, NAD⁺ metabolism, and energy-substrate handling in laboratory settings.